Enrolling now
Primary FSGS
Praliciguat · Phase 2 · NCT07268638
Praliciguat, an oral sGC stimulator, in adults with primary focal segmental glomerulosclerosis whose protein leak persists on a maximally tolerated ACE inhibitor or ARB.
Who it is forAdults with biopsy-confirmed primary FSGS, a urine protein-to-creatinine ratio of 1 g/g or more on a maximally tolerated ACE inhibitor or ARB, and eGFR of 25 or above.
Enrolling now
APOL1-Mediated Kidney Disease
AZD2373 · Phase 2 · NCT06824987
AZD2373 in adults with APOL1-mediated kidney disease (AMKD) who carry two high-risk APOL1 variants (G1 and G2), measured by the change in urine albumin at 30 weeks (APPRECIATE).
Who it is forAdults 18 to 70 of African descent with a high-risk APOL1 genotype, a urine albumin-to-creatinine ratio of 300 mg/g or more, and eGFR of 25 or above.
Enrolling now
Elevated Lipoprotein(a)
Muvalaplin · Phase 3 · NCT07157774
Muvalaplin, an oral lipoprotein(a) inhibitor, for reducing heart attack and stroke risk in adults with high Lp(a) who have cardiovascular disease or are at risk of a first event (MOVE-Lp(a)).
Who it is forAdults with Lp(a) of 175 nmol/L or more who have had a cardiovascular event, or are at high risk of one, including reduced kidney function with diabetes.
Opening soon: ADPKD (Novartis) and Obesity with type 2 diabetes (Eli Lilly). Broader experience across CKD, diabetic kidney disease, IgA nephropathy, anemia of CKD, polycystic kidney disease, resistant hypertension, and dialysis. See the completed-study history.